Week 10 on semaglutide: resting HR up 7 bpm, anyone else tracking?

Opposite trend in a lot of the tracking logs I've seen—RHR down about 4 by week 8. Hydration seems to be the lever there; electrolytes helped.

The part people forget: that same pattern tends to show up in HRV tracking too — dips only for the first 3 weeks after each increase, settled by week 6.

Caffeine same. Sleep shorter because appetite is low and I train later. Not sure it's the med.

I’m not enrolled, but I’ve been watching NCT06897475 because 200 is a decent sample. No HR results posted yet. The 62 in NCT07401992 is small, so I’d treat any wearable signal there as very preliminary. NCT06989203 has 140 and is still recruiting, which is middle ground.

Your glucose shift is interesting—mine went 99 to 94 by week 9, but RHR stayed flat. The trial names don’t tell us much without endpoints, though. I’ve seen a lot of people attribute this to sleep and caffeine, but your HRV drop sounds real. Are you logging morning HR or overnight average?

The glucose drop with flat RHR is the opposite of my pattern. What’s your weekly weigh-in trend?

Down 1–2 lb/week then stalled at week 7. RHR stayed up. CRP didn’t move much for me.

Does it usually settle without a dose change? That’s the thing people end up debating—ride it out, or not. Common surprise: sometimes it does level off on its own; sometimes it doesn’t.

Rode it out and resting HR came down 5 bpm over three weeks. Evening caffeine got cut around the same time, so that muddies it. Sleep tracker showed more wakeups early on, then leveled off.

The trial enrollment numbers are interesting, but without posted HR endpoints it's just noise. Morning readings at the same time every day are what I'd log.

Same-time morning readings made my data way less noisy. Garmin’s overnight average was all over.

Alcohol doe sthat to me too—more than caffeine. Mine adds 6 bpm for two nights.

My RHR went 54 to 62 around weeks 8–12, then slid back to 57 by week 16. The weird part: the turnaround started when I stopped doing fasted morning workouts and ate a real breakfast, not when I hit some week number.

My sleep was also about 25 min shorter, and my Garmin showed that before the HR bump. Down 16 lb and waist is 2.5 in smaller.

Oura user here, and my HRV drop was mostly a weekend-alcohol lie, not this itself. Weeks 7–11 I went from 51 ms to 39 ms, resting HR 56 to 63, and I was sure it was just the weight loss until I looked at the Friday/Saturday graphs.

Two glasses of wine tanked my HRV by 10–12 points and added 4–5 bpm, and that showed up for two days. I cut it out for a month, kept losing about 1.1 lb/week, and HRV came back to 47 by week 15 while RHR stayed 3–4 bpm above my old baseline until week 18.

The sleep length barely changed, but my deep sleep was trash after those nights. Not saying that’s your case, just one variable worth checking if your tracker breaks it out by night.

Mine tracked way more with speed of loss than week number. Any week I dropped over 2 lb, my Garmin RHR jumped 4–6 bpm and HRV fell 8-ish points; at 1 lb/week it stayed flat.

Week 10 was my fastest drop and also a stressful work week, so I stopped weighing daily and added an evening walk. By week 14 it evened out even though I was still losing.

Mine settled around week 13, but HRV lagged a solid month behind RHR. The sleep thing took een longer.

Mine went 56 to 63 around weeks 7-9, and what actually pulled it back down 4 bpm was adding a 20-min after-dinner walk plus one full rest day. I was doing too many hard gym sessions on low sleep. My HRV stayed ugly until sleep steadied, but RHR noticed the recovery first.

Salty takeout night = HRV nosedive, scale up 2 lb, then whoosh. Every time.

I stopped using overnight HRV as my main metric. My Garmin showed a 9 ms drop, but a seated 3-min morning HR was only up 2 bpm.

Turns out my sleep tracker was flagging 'poor' on nights I felt fine and missing the nights I was actually stressed about work. Now I compare weekly averages, not daily scores, and the trend looks way less scary.

My leggings are looser while my RHR is higher—body, pick a lane.

My sleep tracker was the tell for me — I was down to 6:50 a night by week 9 versus 7:35 before, and when I dragged lights-out back 45 minutes for two weeks my resting HR slid from 67 to 62 without changing anything else.

Weird part: my deep sleep number never budged, so the overnight average was lying to me. Check your sleep duration trend before blaming this.