Retatrutide vs the tirzepatide-amylin combo: am I reading the curves right?

2026-10-09 23:48

I keep a nerdy spreadsheet of trial readouts, mostly to guess what might come next for people like me. The tirzepatide + eloralintide combo is the first thing that has made me second-guess retatrutide’s spot at the top of my mental leaderboard.

In the trials, the combo’s weight-loss curves look steeper at similar timepoints, and the amylin piece seems to add satiety without the same GI tax on paper.

But cross-trial comparisons are shaky: different populations, titration schedules, and durations. I’m not changing anything based on a poster. Personal data point: 14 months on tirzepatide, 61 lb down, but my loss has flattened around 183 for six weeks, and my waist tape hasn’t moved either.

That plateau is why the combo data has my attention. For folks who read the actual papers instead of headline charts, what are you watching — lean mass, GI tolerability, or dropout curves?

2026-10-16 12:32

I nerd out on this too. One thing that stopped me comparing raw curves: baseline BMI and % weight loss vs absolute pounds.

A combo trial with a higher average starting weight can look steeper in kg even if the % curve is similar. I switched my own spreadsheet to 4-week rolling % and it exposed that my “plateau” was mostly water/glycogen noise plus fewer steps, not the med failing.

Are you plotting % of starting weight or absolute pounds? And does the combo readout separate lean mass loss?

That’s the part that would actually move my mental leaderboard.

2026-10-18 06:01

I’m in month 4 of a stubborn plateau, so I feel this. One thing trial curves don’t show: my own weekly waist/hip tape and a hunger/food-noise 1–5 score.

Scale’s flat 9 weeks, waist down 1.5in, which makes me wonder how much of the combo’s edge is satiety vs actual fat loss. Sharp question: are you plotting mean % change or median?

A few super-responders can drag an average. Also my sleep and steps tanked right before the stall, and that changed my hunger more than anything.

Anyone else see the curves look better than lived experience?