Week 48: weight down 19 kg, labs flat—anyone else?

Lipid lag is real. LDL basically sits flat for months, then drops about 20 points around month 9. Weight moves way faster the whole time, on a totally different clock.

Month 9? Mine was opposite—LDL early, CRP stuck.

Did you check lean mass? I lost 22 lb but DEXA showed 4 lb lean. Changed how I read the scale.

DEXA is the part I wish I'd done at week 0. My scale says 18 kg down but I have no clue on composition.

NCT04184622 is my rabbit hole too. 2539 people, 72 weeks, 5/10/15 mg. But I can't find granular lab trajectories.

That's why I stopped expecting linear labs. Weight is the headline; markers probably have their own curve.

My hs-CRP dropped 4.1 to 1.9 by week 20, before much weight came off. Lipids took almost a year.

CRP timing seems all over the place—early for some, late for others. Sleep changes?

Sleep tracking worth knowing about: the first 10 weeks tend to be rough, then it evens out. Whether that's the tirzepatide or just finally not snoring — nobody can really say.

Your waist unmber is the one I'd trust more than BMI. Mine went 42 to 36 inches before labs moved much.

I've kept a spreadsheet since week 0. Weight dropped fast weeks 4–16, then plateaued for a month. Fasting glucose came down 99 to 88, LDL actually rose slightly at week 12, then fell by week 40. Your lipid lag and the lean mass question both ring true.

I added lifting twice a week; my rate slowed but clothes fit better and my waist kept shrinking. I wish the 72-week trial had monthly labs, because endpoints hide that non-linear pattern.

Also, the 2539-person enrollment still feels small when you try to slice by response type.

The non-linear lab thing tracks with what I see in my own numbers. Weight down 20 kg, LDL didn't budge until month 10. Monthly labs would be gold.

My labs lagged six months, but my jeans confessed at week 12. Waist tape beats LDL for me.

Sleep is my weird lab: bad weeks, CRP climbs before weight does; good sleep, waist drops first.

Honestly 11 points off LDL in 48 weeks is a win. Lipid panels can be stubborn like that — mine barely budged until month 9.

Weekends wreck me. Friday pizza, Monday scale up 3 lb, labs never notice. I track sodium now.

Mine went the opposite order on liver stuff, weirdly. ALT dropped 38 to 24 by about week 14 and my ferritin slid too, while LDL sat at 138 for six months before it budged at all. Non-HDL ended up more useful to watch than LDL alone. Are you getting a full panel each draw or just the basics?

I only get the good one twice a year so my timeline looks choppy even when things are moving.

The part people forget is the labs can move first while the scale sulks. A1c going 5.9 to 5.5 by week 20 of tracking, while the scale gives up maybe 6 lb that whole stretch, is a real pattern.

Then weeks 24 through 40 it catches up, about 22 lb down, and the labs go flat. One fasting draw can also read flat if you were low on fluids that morning, so it’s worth not over-reading single sets.

Not a lab thing, but my tape measure moved long before my scale did. Weeks 30 to 38 the scale was honestly flat, same 182 to 183 every morning, but my waist went 40 to 36.5 and I dropped a shirt size.

What changed was lifting 3x a week and pushing protein from around 110g to 135g, plus walking went 8k to 11k steps. The first month I ate back every calorie I burned and netted zero, so that was a real fail on my part. Where do you measure, navel or natural waist? Mine reads two inches different depending on the spot.