Week 14: fasting glucose up while weight down—anyone else?

Fasting glucose can drift if you're eating way less and sleeping bad. Mine went 92 to 101 around week 10, then back to 95 by week 16. CGM showed dawn spikes, not the semaglutide itself.

Anyone mess with protein or workout timing and seen the 6-8am dawn spike move at all? That window seems locked in no matter what.

Mine did opposite. Fasting dropped first, weight lagged till week 8.

NCT06897475's listing says 200 enrolled. Not much gets shared beyond that, but the fasting glucose logs are definitely part of the routine — feels like a lot of tracking for a trial that stays this quiet.

Are they doing CGM or just fingersticks? I'm curious how often they pull A1c.

Worth knowing before you compare anything: the monitoring side of it is just fingersticks and one lab draw. And that 200 is total planned enrollment, not everyone dosed yet.

I've seen the 62-enrolled study too. That's tiny. Hard to draw conclusions from small n.

Small n doesn't mean useless, but I wouldn't compare across trials with different designs.

My fasting glucose rose for a few weeks when I was basically under-eating. Once I added a real dinner and slept seven hours, it came down. Not saying that's what's happening to you, just that weight loss and glucose don't always move together.

I also noticed the 62-enrolled NCT07401992 and the 140 in NCT06989203 are still recruiting, so any early forum comparisons are going to be messy. The 609-enrolled NCT07011667 is the one I'd watch if it posts data. What did your overnight CGM look like before the fasting draw?

Under-eatin gmade mine worse too. I thought lower calories = lower fasting, but no.

Protein at 70g while lifting 3x? That's low.

I'm waiting for my next labs before changing anything. Trends beat single readings.

Mine did the same dumb thing around week 12 and it had almost nothing to do with the weight coming off. I was sleeping about 5.5 hours, lifting at 8pm, and eating dinner at 9:15 because my appetite didn't show up until evening — fasting went 91 to 103 over about three weeks.

My post-meal numbers got better at the exact same time, which felt completely backwards. What pulled the morning number back down was boring stuff: dinner by 7, lifting before 5pm, closer to 100oz of water, and testing at the same 10 minutes after waking instead of whenever I rolled out of bed.

It drifted back to 93-96 by week 21.

Worth knowing whether that 104 was a one-off lab draw or your usual routine, because a 6am draw after a late workout and bad sleep is a different animal than a normal Tuesday.

My fasting number is always the last one to get the memo. Scale drops, waist shrinks, glucose just sits there jdging me.

I'll be the disagreeable one: my fasting glucose got worse when I was eating the least. Weeks 8 through 15 I was probably under 1400 calories most days and my morning number hung out between 100 and 106 the whole time, even while I was dropping about a pound a week.

Less food in means less glycogen, so your liver just tops you up overnight and the morning read looks higher. Mine started coming down once I added a real carb serving at dinner and stopped doing fasted cardio at 6am.

Also, eating way less usually means drinking way less — I was lucky to hit 50oz of water and I'm sure that didn't help. A1c is a 3-month average, so it lags whatever you changed in the last six weeks; I'd watch the 4-week trend instead of one number.

My morning number tracks my sep count harder than anything else — 8k+ days and I'm low 90s, under 4k and I'm 100+. Are you walking on rest days? That was my gap. Lifting three times a week did nothing for my fasting, but 25 minutes after dinner dropped it 6-8 points.

16 weeks of logging seems to be the magic number for this realization. Common surprise: fasting barely budges — 98 to 103, basically flat — while the 2-hour post-dinner number drops from the 150s to the 120s. Nobody warns you that's the one that actually moves.

The part people forget is that the morning stick can end up being the least useful number in the whole log, since it's the after-meal reading doing all the talking. Worth knowing before comparing options or deciding whether anything's working. So what do your after-meal readings look like?

Mine turned out to be dinner timing. Eating at 8:30pm versus 6:30pm, roughly the same food, and my morning number ran 7-8 points higher on the late nights. Took me a solid month of CGM data to see it because I kept blaming the food itself. Worth jotting down yur last bite time for a week, it's a cheap experiment.

Adding a non-scale angle: my jeans went from tight in the thigh to genuinely loose a good two weeks before the scale moved at all, and during that same stretch my morning number looked terrible. Sodium and water seem to swing that reading way more than actual fat loss does week to week.

Do you have a waist or jeans checkpoint, or is it scale plus labs only?