I keep coming back to NCT04184622: 2,539 people, four arms (placebo, 5, 10, 15 mg), primary period Week 0–72. I’m at week 28 on my own chart and my A1c finally crossed into normal range, but I never moved past 5 mg.
What I can’t find is raw Week 72 outcome numbers broken out by dose. Did anyone else here keep a spreadsheet?
I’m not asking what I should do—just curious whether 5 mg completers look meaningfully different from the 10/15 arms.
I’ve dug through NCT04184622 too. Public record gives enrollment and arms, not Week 72 by dose. Exact per-arm outcomes are either from a paper or guessing.
The 2,539 number makes me trust it more. Big enough that the 5 mg arm isn’t just noise, even if it’s not the headline.
Not sure I follow the 5 vs 10 comparison. If the primary period is Week 0–72, don’t dropouts and dose escalations blur the arms?
Dropouts definitely blur it. A notebook with weekly weight, side effects, whether the 5 mg step held steady — that's still just tracking. An A1c landing back in normal range is one person, not an arm.
One-liner: my labs improved before the scale did.
Same. Week 72 completers matter more than averages. People who tolerate 10 or 15 mg may be a different group than 5 mg folks.
That’s the selection effect I keep circling. The 5 mg arm may include people who never escalated for tolerance reasons, and the 10/15 arms may include people who could handle more.
Unless a report gives completion rates by arm, comparing raw Week 72 numbers is messy. I’d like a simple table: started, completed, stayed at assigned dose, lab changes, side effects. Not treatment advice—just transparency.
The 2,539 enrollment is solid, but the breakdown is where the interesting stuff hides. If the 5 mg group has more early non-completers, the Week 72 average is a survivor club.
A forum won’t produce that table. The record lists placebo, 5, 10, 15 mg over Week 0–72, but no outcomes. The atrial fib and LY3457263 trials won’t answer this either.
Question back: are you tracking waist or lean mass? Weight alone can make 5 mg look worse or better depending on what’s changing.
I track waist and fasting glucose, not just weight. My glucose is the most stable number. Waist is slower, but it moved eventually.
I appreciate the spreadsheet angle. I did a basic one for my own use—date, dose, side effects, hunger, labs—and it helped me see patterns I’d have missed. But I’d never claim it maps onto a 2,539-person trial.
The fact that NCT04184622 ran to Week 72 with four arms is useful context; it doesn’t tell us what any individual should do.
Tape measure, not A1c, was the real scoreboard: three inches gone by week 28, then weeks 29-36 dead flat. Nothing.
My spreadsheet says weekends undo weekdays: 1,900 weekday steps vs 6,000 Saturday, and scale jumps two lb every Monday.
Sleep is my weird marker: under six hours, cravings spike and my weekly loss flips to a 0.4 lb gain, no food change.
Contrarian: I stopped weighing daily and used a too-tight jeans benchmark; hit a new notch week 31, scale hadn't moved in 18 days.
I stopped trusting the scale and started tracking resting heart rate plus waist tape at the navel, same spot, Sunday mornings before coffee. Week 30 here: RHR went from 74 to 66 and I'm down 2.5 inches at the waist while the scale sat on the same number for six weeks straight.
Honestly my doctor cared more about the tape than the pounds.
If that Week 72 per-arm breakdown ever drops, my guess is it's buried in a supplement table, not the main figure.
The 5 arm is the one I keep refreshing on too, half of us stayed put and nobody publishes that slice.
Gym was the surprise for me. I added two 30-minute resistance sessions a week around week 22 plus 8k steps on workdays, and the scale froze for seven weeks while my 5k went from 41 minutes to 33 and my grip test jumped 6kg. I'll take that trade. Are you logging anything besides A1c, like waist or resting HR?
@h0lly41 said:
the scale froze for seven weeks while my 5k went from 41 minutes to 33. I'll take that trade.
Relatable fail first: I kept a spreadsheet like yours for months, then went to Costco hungry at week 34 and bought a four-pack of croissants “for the freezer.” Ate two in the car. What actually saved my log was pre-logging before I shop, checking the week’s protein lands near 100g a day before I leave the house.
Breakfast alone is 30g, eggs plus Greek yogurt, and that cut my 4pm vending trips from five days a week to one. On your question, I dug through the registry and I think the Week 72 per-dose numbers only ever show up as a supplement table, and completers versus everyone enrolled tell different stories, so whoever posts a number here, ask which denominator they used.
Are you tracking A1c only, or waist and resting HR too?
Login to reply to this thread.
Login / Sign up