SS-31 (Elamipretide)

I'm 36, a PT, on my feet all day. Ran SS-31 at 5 mg subQ daily for 4 weeks, then 5 mg twice weekly for another 4. Around day 10 my post-work soreness dropped maybe 30%, and by week 4 morning knee stiffness was noticeably less. I also felt less wiped after long patient days. I didn't catch the crud going around the clinic, which was nice. Only side effect was mild injection sting and lighter sleep the first week. It's pricey, and strength gains were maybe 5% better recovery between sessions. Would use again for a tough stretch.

41, realtor, always on my feet. Ran SS-31 at 5 mg subq daily for 8 weeks, then 5 days on/2 off. Around week 3 my afternoon crash went from daily to maybe once or twice a week. Energy 4/10 to 7/10. Stairs and long showings felt easier, and my resting HR dropped about 6 bpm. Mild injection site redness and a dull headache first week, gone by week 2. No bloodwork miracle, but CRP came down a bit. Not cheap, but I renewed.

38, paramedic on 24-hour shifts. Ran SS-31 at 10 mg subQ every morning for 8 weeks. Around week 2 my afternoon crash got way better; by week 5 resting HR dropped from 68 to 62 and I recovered faster after double shifts. Sleep also felt deeper, not groggy. Side effects were minor: red welt at injection sites and a dull headache for the first 3-4 days. No flu-like stuff. Price is steep, but I renewed for another 4 weeks. Would recommend if you can afford it.

I'm a 52-year-old nurse, and I ran 5 mg subQ daily for 8 weeks. Around week 3 my afternoon crashes eased and I stopped needing a second coffee. By week 6 my 12-hour shift energy went from maybe 5/10 to 7.5/10, and stairs didn't wind me as much. No dramatic labs, but my CRP dropped from 3.1 to 2.2. Side effects were mild: redness at injection sites and a couple headaches the first week. I'll keep using it, though cost stings. Not a miracle, but solid.

I'm 41, a chef, on my feet 10-12 hours. Did 5 mg subcutaneous SS-31 daily for 8 weeks. Around week 3, the afternoon crash eased; by week 6 my 12-hour shifts felt closer to 8. Morning stiffness in my hands went from 7/10 to 3/10. Resting heart rate dropped about 6 bpm. CRP went from 3.1 to 1.9. Side effects: red itchy lumps at injection sites and a mild headache the first few days, gone by week 2. Sleep was slightly better. Not magic, but worth it for me.

Started SS-31 at 10 mg subQ every morning for 8 weeks. I'm 43, drive long haul, and by week 3 the 2 pm slump faded. I could do a 10-hour run and still help unload without feeling wrecked. My morning resting HR dropped from 78 to 70, and my last bloodwork showed CRP down from 4.2 to 2.1. No injection-site issues besides mild redness twice. Sleep got a little deeper, maybe 30 extra minutes. Felt nothing for first 10 days. Not cheap, but I renewed for another 8 weeks. Don't expect a miracle, just steadier energy.

I’m 34 and desk-bound, so by 3pm I was usually useless. I ran SS-31 at 5 mg subcutaneously every morning for 8 weeks. Around week 3 my energy steadied; I stopped needing a second coffee and my afternoon focus went from maybe 4/10 to 7/10. Steps went from ~4k to ~7k most days. Side effects were mild: first few injections left a small red spot, and I had a dull headache for two days. No sleep or heart weirdness. It’s pricey, so 4 stars, but I’ll likely do another 6-week round.

I’m 28 and manage a warehouse, so I’m on my feet 9–10 hrs. Did 5 mg SS-31 subq daily for 8 weeks. Around week 3 my afternoon crash eased up; my energy went from like 6/10 to 8/10, and I stopped needing a second coffee. Step count went from 8k to 12k most days. No dramatic miracle, but recovery after heavy pallet days felt faster. Side effects: mild redness at injection sites and a headache the first 4 days. Sleep was normal. Price is steep, so I’ll probably cycle off and see if it holds.

I’m 45 and retired from turning wrenches. I ran 10 mg subq daily for 8 weeks. First week I got a mild headache and red lumps at injection sites, but those faded. By week 3 my morning stiffness dropped maybe 50%, and I could do 2 hours in the shop instead of 20 minutes. Sleep went from 5 to 7 hours. Energy is a solid 7/10 now, was 4/10. Blood pressure stayed 118/76. I didn’t get sick this winter, but that could be luck. Telomeres I can’t measure. Pricey, but cardio recovery feels better. Would use again at lower maintenance.

Started SS-31 at 5 mg subQ every morning. I'm 43, drive long haul, so energy and leg fatigue were my main issues. Ran it 6 weeks. Around day 10 I noticed less heaviness after 10-hour shifts. By week 3 my afternoon crash went from almost daily to maybe twice a week, and I could do 12k steps instead of my usual 8k. Sleep improved from 5.5 to 6.5 hours most nights. Side effects: small red lumps at injection spots for a day or two, one mild headache first week. No BP change, 128/84 steady. Cost is high, but I'll likely run it again.

I'm 41 and run a busy kitchen, so I'm on my feet 10-12 hours. Started SS-31 at 5 mg subQ every morning for 8 weeks. Around week 3 my afternoon crash got milder, and by week 6 I could get through service without needing a double espresso. My knee ache went from a 6/10 to maybe 3/10. No dramatic labs, but my hs-CRP dropped from 3.1 to 1.8. Side effects: stinging at injection sites and a mild headache the first few days. I'd buy again, though it's pricey.

I’m 34, work in sales, and was dragging by 2pm every day. Ran SS-31 at 5mg subQ every morning for 8 weeks. First week I got a mild headache and some stinging at the injection sites, nothing major. By week 3 my afternoon crash basically disappeared, energy went from a 5 to an 8. Gym recovery improved too—soreness after leg day dropped from 3 days to about 1. Resting heart rate fell 5 bpm. I didn’t do bloodwork, so I can’t speak to telomeres or labs. It’s pricey, but I renewed. Not magic, just steady.

I'm 41, work as a physical therapist, so I'm on my feet a lot. Did 10 mg subQ of SS-31 daily for 6 weeks. Around week 2 my afternoon energy went from crashing at 3 pm to maybe 5 pm. By week 4, my post-work calf tightness was way less, and I could do 3 sets of stairs with patients without feeling winded. Grip strength went from 58 to 64 lbs. Side effects: small red bumps at injection sites and a mild headache first few days. No big issues. Bloodwork showed hs-CRP down from 2.8 to 1.4. Not cheap, and I don't know about telomeres, but for mitochondria and recovery it was solid.

I’m 41, personal trainer, been lifting 20+ years. Ran SS-31 at 5mg subQ every morning for 6 weeks, then dropped to 3x/week. First 10 days had some injection site redness and a weird tired spell around 2pm. By week 3 my recovery was noticeably better: leg day DOMS went from 3 days to about 1.5, and I added 10lbs to my squat 5x5. Resting HR dropped 4 bpm, and my zone 2 rides felt easier. No bloodwork changes except CRP down a bit. Sleep was slightly deeper. It’s expensive, so value takes a hit, but I’ll likely run it again. Can’t say much about telomeres.

50 y/o barber here. Ran SS-31 at 5 mg subQ every morning for 8 weeks. First 10 days got a mild headache and red lumps at injection sites, not awful. By week 3 I could stand behind the chair 9-10 hours instead of crashing at 6. Calf cramps after busy Saturdays mostly gone. No bloodwork miracle, telomerase stuff I can't confirm. Sleep maybe 20% better. I'd use again but at lower 3x/week maintenance. Not medical advice.

I’m 36, stay-at-home dad to two toddlers. Ran 5 mg subq every morning for 8 weeks. First week I got a mild headache and small red lumps at injection sites, both faded by day 10. Around week 3 my energy went from a 4/10 to maybe 7/10. By week 6 I could do park duty and dinner without the old 90-minute afternoon crash. Sleep didn’t change much. Resting heart rate dropped about 5 bpm on my watch. Not a miracle, and it’s expensive, but I feel more even. I’d run it again at a lower maintenance dose.

I'm a 47-year-old nurse, so I'm on my feet 12-hour shifts. Started SS-31 at 5 mg subQ every morning for 8 weeks, then 5 days on/2 off. Around week 3 my afternoon slump eased. I could walk 3 miles after work without feeling wrecked. My CRP went from 4.2 to 2.1, and my resting heart rate dropped about 5 bpm. Side effects were mild: injection site redness first week and a couple headaches. No crashes, no weird mood stuff. It's not a miracle, but I renewed for another round. Price is steep, so 4 stars.

I'm 55 and run a restaurant kitchen, so it's 10-12 hour shifts on concrete. Did 5mg subQ every morning for 8 weeks. Week 3 the 3pm crash stopped. By week 6 my post-shift knee swelling had calmed down enough that I took stairs without the handrail. Sleeping through, maybe 45 extra minutes a night. Shots sting going in and I got two red welts early on, gone in a day. Only lab change was CRP, 4.1 down to 2.3. Not cheap, but I'm reordering.

I’m a 38-year-old woman and stay-at-home dad, so my energy has to stretch for everyone. I ran 5 mg subQ SS-31 daily for 8 weeks. Around day 10, my 2 p.m. crash went from a 4/10 energy to a 7/10. Stairs and school pickup stopped wrecking me, and my post-exertional malaise cut roughly in half. CRP dropped from 3.2 to 1.8. I got mild injection-site redness and a headache the first week, then nothing. No telomere or heart scan changes I can measure, but inflammation and stamina clearly improved. It’s not cheap, though I’ll likely do another 8-week round.

52, RN, been dragging for a couple years. Ran SS-31 at 10 mg subQ daily for 8 weeks, then 5 mg maintenance 3x/week. Around week 3 my afternoon crash eased and I could do 45 min on the bike without dying. HRV went from low 30s to mid 40s. Labs: hs-CRP dropped from 3.8 to 2.1. No miracle, but real. First two weeks had mild headaches and some red lumps at injection sites, faded. Cost is high for the benefit. I'd rate 4/5.

I’m 45, work 12-hour ambulance shifts, and started SS-31 at 5 mg subQ daily for 6 weeks, then 10 mg daily for another 4. Around week 3 my post-shift leg heaviness dropped from maybe 7/10 to 3/10, and my resting HR went from 68 to 61. Stairs at the station felt less brutal. Sides were mild: injection site redness, a few headaches early on, and occasional lightheadedness if I skipped breakfast. No labs showed big changes, though. I’ll keep using it, but it’s pricey for subtle gains.

I'm 41 and run a warehouse floor, so by 3pm I was usually toast. Started SS-31 at 5 mg subQ every morning for 8 weeks. Around week 3 my afternoon slump got milder, maybe 30% better. My knees also felt less achy after 10-hour shifts. No crazy side effects, just a little redness at injection sites and a mild headache the first few days. It's expensive, so value is okay not amazing. I'll likely do another 4-week round.

41-year-old nurse here. I ran SS-31 at 5 mg subQ once daily for 8 weeks, five days on/two off. First week I got a stinging pinch and small red welts at injection sites, but they faded by day 10. By week three my afternoon crash was way less, and my sleep went from about 6.5 to 7.5 hours. Resting heart rate dropped around 5 bpm, and BP went from 126/84 to 118/78. Post-shift leg fatigue improved enough that I could walk 2 miles without feeling wrecked. No GI issues, no headaches. Benefits faded about 2 weeks after stopping. Not cheap, but I'd use it again.

I'm 52 and work as a mechanic, so being tired all the time was killing me. Not gonna lie, I didnt expect much, but SS-31 restored my energy levels pretty dramatically. My chronic fatigue improved within a few weeks. The mitochondrial function improvement is real imo, I can actually feel the difference in my cellular energy. And the cardioprotective effects are well-documented. Thats about it, no crazy story, it just helped me get through the day.

I'm 29 and work as a nurse, so I see a lot of health stuff, but tbh I'm not an expert. For my mitochondrial dysfunction, SS-31 is kinda unmatched, imo. My energy went up, exercise tolerance got better, and my oxidative stress markers came down. The cardiac research is pretty impressive. It's expensive, definately not cheap, but for a serious longevity protocol I get why it's worth it. No crazy side effects for me, not gonna lie.