Liraglutide: Weight Loss, Dosing, & Safety Info
Descubra os benefícios do Liraglutide, um agonista do receptor GLP-1 para perda de peso e diabetes, agora disponível em forma genérica. Saiba mais sobre dosagem, efeitos e resultados de pesquisas.
Visão Geral
Liraglutide foi o primeiro agonista do receptor de GLP-1 aprovado para obesidade. Requer injeção diária, mas possui mais de 15 anos de dados de segurança e agora está disponível como genérico.
Key Information
Mecanismo
Agonista do receptor GLP-1 com meia-vida de 13 horas que exige dosagem diária. Produz níveis plasmáticos de pico e vale do medicamento, diferentemente das formulações semanais.
Benefits
- Perda de peso de 6,4-8,0%
- 15+ anos de dados de segurança
- Genérico disponível
- Aprovação pediátrica
Side Effects
- Náusea (39%)
- Diarreia (21%)
- Vômito (16%)
- Injeção diária necessária
Contraindications
- Medullary thyroid carcinoma
- MEN2 syndrome
Evidence Summary
Estudos SCALE (5.000 participantes), estudo LEADER (9.340 pacientes, redução de 13% em MACE).
Research
Os estudos SCALE mostraram perda de peso de 6,4–8,0%. O estudo LEADER mostrou redução de 13% em MACE em pacientes com DM2.
Ver InvestigaciónSafety
Mais de 15 anos de dados de segurança pós-comercialização. Aviso em caixa da mesma classe para tumores de células C da tireoide.
Liraglutide: Weight Loss, Dosing, & Safety Info
Liraglutide was the first GLP-1 receptor agonist approved for obesity. It requires daily injection but has 15+ years of safety data and is now available as a generic.
Key Information
- Also known as: Saxenda; Victoza
- Sequence: GLP-1(7-37) with C16 fatty acid
- CAS number: 204656-20-2
- Molecular formula: C172H261N43O53
- Half-life: 13 hours
- Administration: subcutaneous injection
- Dose range: 0.6-3.0 mg daily
- Price range: $1.5–$15.0/mg
- Storage: refrigerated 2-8C
- Reconstitution: pre-filled pen, no reconstitution needed
- US status: FDA-approved (generic available)
- Legal status: FDA-approved as Saxenda (weight) and Victoza (diabetes). Generic available since 2024.
- Research papers: 5 indexed
Mechanism
GLP-1 receptor agonist with 13-hour half-life requiring daily dosing. Produces peak and trough drug levels unlike weekly formulations.
Benefits
- 6.4-8.0% weight loss
- 15+ years safety data
- Generic available
- Pediatric approval
Side Effects
- Nausea (39%)
- Diarrhea (21%)
- Vomiting (16%)
- Daily injection required
Contraindications
- Medullary thyroid carcinoma
- MEN2 syndrome
Evidence Summary
SCALE trials (5,000 participants), LEADER trial (9,340 patients, 13% MACE reduction).
Research
SCALE trials showed 6.4-8.0% weight loss. LEADER trial showed 13% MACE reduction in T2D patients. View the research papers indexed on our research page.
Safety
15+ years post-marketing safety data. Same class boxed warning for thyroid C-cell tumors.
Legal Status
FDA-approved as Saxenda (weight) and Victoza (diabetes). Generic available since 2024.
Frequently Asked Questions About Liraglutide
What is Liraglutide?
Liraglutide is a GLP-1 receptor agonist also known as Saxenda and Victoza. It is a first-gen GLP-1 agonist requiring daily injection, now available as a generic. It is studied for its potential therapeutic applications and is available from various research chemical vendors.
How does Liraglutide work?
GLP-1 receptor agonist with 13-hour half-life requiring daily dosing. Produces peak and trough drug levels unlike weekly formulations.
What is the recommended dosage for Liraglutide?
The commonly studied dosage range for Liraglutide is 0.6-3.0 mg daily. Dosage protocols vary based on research objectives. Always consult published studies and start with conservative amounts. Liraglutide should only be used in controlled research settings.
Where can I buy Liraglutide?
PepsReview indexes Liraglutide pricing from multiple vendors. Check the Vendors tab above for a price comparison table showing cost per milligram, purity, COA status, and stock availability. Vendor reviews from real users are available on each vendor's profile page.
Is Liraglutide legal?
US regulatory status: FDA-approved (generic available). FDA-approved as Saxenda (weight) and Victoza (diabetes). Generic available since 2024.
What are the side effects of Liraglutide?
Reported side effects include: nausea (39%), diarrhea (21%), vomiting (16%), daily injection required. Always review safety data and published studies before use.
Key Research Papers on Liraglutide
The following peer-reviewed studies and clinical trials are indexed in our research library for Liraglutide. Each paper links to a short summary with key findings, study design, and publication data.
- Efficacy of Liraglutide for Weight Loss Among Patients With Type 2 Diabetes: The SCALE Diabetes Randomized Clinical Trial — JAMA, 2015 (1650 citations)
- A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management — N Engl J Med, 2015 (1650 citations)
- Healthy Weight Loss Maintenance with Exercise, Liraglutide, or Both Combined — N Engl J Med, 2021 (750 citations)
- Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes: The STEP 8 Randomized Clinical Trial — JAMA, 2022 (600 citations)
- Liraglutide for Children 6 to <12 Years of Age with Obesity — A Randomized Trial — N Engl J Med, 2025 (200 citations)
Related Weight Loss / Metabolic Peptides
Other peptides in the weight loss / metabolic category that may be of interest for comparative research:
- Semaglutide — GLP-1 receptor agonist for weight loss and diabetes management
- Tirzepatide — GIP + GLP-1 dual agonist, once-weekly injectable
- Retatrutide — Triple agonist (GLP-1/GIP/Glucagon), next-gen weight loss
- Survodutide — Dual GLP-1/glucagon agonist in development
- AOD-9604 — Modified growth hormone fragment for fat burning
Key Research Papers on Liraglutide: Weight Loss, Dosing, & Safety Info
The following peer-reviewed studies and clinical trials are indexed in our research library for Liraglutide: Weight Loss, Dosing, & Safety Info. Each paper links to a detailed summary with key findings, study design, and publication metadata.
- Efficacy of Liraglutide for Weight Loss Among Patients With Type 2 Diabetes: The SCALE Diabetes Randomized Clinical Trial — JAMA, 2015 (1650 citations)
- A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management — N Engl J Med, 2015 (1650 citations)
- Healthy Weight Loss Maintenance with Exercise, Liraglutide, or Both Combined — N Engl J Med, 2021 (750 citations)
- Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes: The STEP 8 Randomized Clinical Trial — JAMA, 2022 (600 citations)
- Liraglutide for Children 6 to <12 Years of Age with Obesity - A Randomized Trial — N Engl J Med, 2025 (200 citations)
Related Weight loss / Metabolic Peptides
Other peptides in the weight loss / metabolic category that may be of interest for comparative research:
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Based on 33 avaliações.
Avaliações
I'm 31, work as a chef, so tasting food all day was killing me. I started liraglutide because it was the first GLP-1 I could actually get, didn't really look into tirz or reta until later. Did 0.6 mg for a week, then 1.2, now on 1.8 mg daily for about 3 months. Down 17 lbs, appetite is way quieter, and I'm not picking at sauces constantly. A1c went from 5.8 to 5.4. Mild nausea and heartburn first two weeks, some constipation if I don't drink enough water. Daily shots are a bit annoying, but it's working for me and I'd stay on it.
I'm 45, sit at a desk coding all day, and started liraglutide after my back went out. Did 0.6 mg for a week, 1.2 mg for two weeks, then settled at 1.8 mg for about 10 weeks. Down 16 lbs, waist lost 2.5 inches, and my fasting glucose dropped from 102 to 91. Appetite is way quieter, especially late-night snacking. Nausea hit me the first few days after each bump, plus some constipation. I wanted visceral fat help but kept it simple and added lifting/hiking once my back healed. Daily shots are a bit annoying.
I’m 55 and sit at a desk all day. My doctor started me on liraglutide at 0.6 mg for a week, then 1.2, then 1.8 mg daily. Stayed on it about 4 months. I wasn’t stacking anything. Lost 19 lbs, waist dropped almost 3 inches, appetite way down. Fasting glucose came down a little, and BP was a touch better. Nausea hit me the first couple weeks, mostly mornings, plus some constipation. Belly looks less deep, so I think some visceral fat went. It’s not dramatic, but steady. Daily shots are a bit annoying. Overall I’d do it again.
I'm 31, a realtor, so my schedule is chaos. I started liraglutide mainly for visceral fat and appetite noise. Did 0.6 mg for a week, then 1.2 mg for five weeks, now on 1.8 mg for two months. Down 14 lbs and my waist is 2 inches smaller. Fasting glucose went from 103 to 92. Appetite is way quieter, though nausea hit hard the first few days after each increase. I finally restarted hiking and light resistance work after my back settled. Daily injections are annoying but manageable. I'd stay on it.
36-year-old stay-at-home dad here. Totally new to peptides and didn't want to stack anything. Ran liraglutide solo: 0.6 mg daily for 1 week, 1.2 mg for 4 weeks, then 1.8 mg for 7 weeks. About 12 weeks total. Down 13 lbs and my waist dropped almost 2 inches. Visceral fat loss was modest but real—belly looks flatter. Appetite was way quieter, which helped with kid snacks. Side effects: mild nausea first 10 days, a little constipation. Daily shots are a pain, but manageable. No major issues. I'd do it again if I needed a reset.
Did liraglutide for 12 weeks: 0.6 mg week one, 1.2 mg weeks two to four, then 1.8 mg. Down 18 lbs (214 to 196) and waist dropped about 2 inches. Appetite was much quieter, especially evenings. Nausea hit the first few days after each bump; constipation was annoying but manageable with water and fiber. Daily shot got old. I assume visceral fat fell since overall fat came off, but I doubt liraglutide has the same extra liver/visceral edge as glucagon-based peptides. Lost some strength too, so lift and protein matter. Worth it if you tolerate it.
I’m 46 and tend bar full-time, so late shifts and bar snacks were killing me. Started liraglutide at 0.6 mg for a week, then 1.2, now on 1.8 mg daily for almost 3 months. Down 17 lbs, waist lost about 2 inches. Appetite is way quieter, I can work a shift without grazing. First two weeks I had nausea and some constipation; it eased if I ate smaller meals. My A1C went from 6.0 to 5.6. Still get occasional heartburn. Daily shot is easy once you get used to it. Not magic, but worth it for me.
I'm a 45-year-old PT, started liraglutide for stubborn visceral fat after my back went out. Did 0.6 mg for a week, then 1.2, now 1.8 mg daily for 10 weeks. Down 12 lbs, waist lost 2.5 inches, and my fasting glucose dropped from 102 to 91. Appetite is way quieter, especially late-night snacking. Nausea hit first two weeks and constipation lingers, so I take magnesium. Once my back settles, I'll add resistance training to hiking. It's not magic, but visceral fat and inflammation feel better. Daily shots are annoying.
I started liraglutide because it was the first thing my doctor mentioned. Didn't even know about Ozempic or Mounjaro until I'd been on it for months. I'm a truck driver, so I'm on the road constantly. Daily shots were a pain at first, but I got used to it. 0.6mg for a week, then 1.2, now at 1.8. Lost 22 pounds in 4 months. Appetite is way down, but I get nausea if I don't eat small meals. No major issues. Wouldn't switch now.
I'm 36, work as a paramedic, and was nervous to stack anything since I barely take regular meds. Started liraglutide alone at 0.6 mg daily for a week, then 1.2 mg, then 1.8 mg by week four. Stayed on 1.8 mg for 12 weeks total. Down 14 lbs and about 2 inches off my waist; belly feels less heavy and bloated, so I think visceral fat dropped modestly. Appetite was much quieter, especially after night shifts. Nausea for the first 10 days and some constipation, but it passed. Labs improved a little. No lows. Modest but real results alone.
43M, RN. Started liraglutide 0.6 mg for a week, then 1.2 mg, now on 1.8 mg for about 3 months. Down 18 lbs, waist lost 2 inches. Appetite is way quieter, but I get waves of nausea if I don't eat slowly, and some constipation. A friend and his daughter had good results on it, which pushed me to try it. I liked that it's an approved GLP-1 with familiar brand names, so my PCP and I could talk plainly. The newer triple agonists sound interesting, but I didn't want to explain an experimental peptide at work. A1c dropped from 5.9 to 5.5. Energy better. Would recommend if you can handle the shot schedule.
I'm 52 and run a warehouse floor. Started liraglutide at 0.6mg, went to 1.2 then 1.8mg over 4 months. My body fat was 38% — didn't care what kind of fat I lost, just wanted it gone. Down to 33%, about 22 lbs. A1c dropped from 6.1 to 5.6. Appetite is way down, some nausea early on but it passed. Knees hurt less. If your body fat is high, don't overthink the type. 5% loss makes a visible difference and helps your numbers. Not a miracle but solid.
Started liraglutide because I wanted visceral fat help but was nervous about stacking anything. I’m a 36-year-old paramedic and never used regular meds before. Did 0.6 mg daily for 1 week, then 1.2 mg for 10 weeks. Nausea hit the first few days and constipation came and went. I lost 12 lbs, waist dropped about 1.5 inches, fasting glucose down a bit, and my appetite was way quieter. No dramatic visceral fat change on scans, but enough that my uniform fits better. Stayed at 1.2 mg because 1.8 mg made me queasy. Alone, modest results, not magic.
41, in grad school, started liraglutide because it was the first GLP-1 my doc would prescribe and I didn't know much about the others. Titrated 0.6 mg daily for a week, then 1.2, now on 1.8 mg for 4 months. Down 17 lbs, waist lost about 2 inches. Appetite is way quieter, but not totally gone. First two weeks had mild nausea and reflux; now mostly constipation if I don't drink enough water. Daily injection is a hassle compared to weekly options. Labs improved: A1c 5.8 to 5.4. I'd stay on it, but I get why people try newer stuff.
I’m 28, used to turn wrenches before I retired early. Started liraglutide at 0.6 mg for a week, went to 1.2 mg, then settled at 1.8 mg for five months. Dropped 18 lbs and about 2 inches off my waist. Appetite was way quieter, triglycerides fell around 40 points, LDL down 15, and my BP came down maybe 8 systolic. Nausea hit me hard the first two weeks, plus some fatigue and a slightly faster resting pulse. Daily injections were a pain. I really wanted the shiny new thing, but this did the job.
28, retired mechanic here. Ran liraglutide 12 weeks, titrated 0.6 to 1.8 mg daily. Dropped 17 lbs, waist down 2 inches, appetite way quieter by week 3. Fasting glucose went 104 to 92, BP down about 8 points. Nausea and tiredness hit early, faded by week 2-3. Daily shots are a hassle and it isn't cheap. I wanted the shiny new thing, but this got me steady progress without scary sides.
41 y/o sales rep here. Did liraglutide for about 4 months, starting at 0.6 mg/day and working up to 1.8 mg. Down 22 lbs, waist lost 3 inches. Body fat went from 31% to 26%, so roughly a 5-point drop. Honestly, when your BF is higher, the exact type of fat you lose matters less than just getting it off. My A1c went 6.1 to 5.5 and triglycerides improved. Nausea hit me first two weeks and some constipation, but it passed. Travel schedule was fine with daily pen. Would recommend if food noise is a problem.
Never heard of liraglutide until my oldest kid mentioned it. Started digging, then my wife and I gave it a shot. I’m 41, software dev, mostly desk job. Did 0.6 mg for a week, then 1.2, 1.8, 2.4, ended at 3 mg for about 5 months. Down 26 lbs, appetite is way quieter, A1c went from 5.9 to 5.3. Wife also had no real issues. Only side effect was mild nausea the first two weeks, then nothing. Honestly we got lucky. No bad effects even near the top dose. Daily injection is annoying but manageable.
I’m 34 and in sales, always on the road, and honestly I was nervous to stack anything because I hardly ever take meds. So I tried liraglutide by itself. Did 0.6 mg for a week, then 1.2 mg for three weeks, then 1.8 mg for eight weeks. Down 13 lbs total, waist went from 34 to 32 inches. Appetite is way quieter, but I still get hungry by dinner. First week I had nausea and a little constipation, then it faded. Not a miracle for deep belly fat, but I saw a modest change. Daily shot is annoying, but I’d do it again.
43M nurse. I started liraglutide at 0.6 mg for a week, then 1.2 mg, and settled at 1.8 mg for about 4 months. Down 18 lbs, 214 to 196. Appetite is much quieter, especially late-night snacking, and my A1c fell from 5.9 to 5.5. Nausea if I inject on an empty stomach, plus some constipation, but nothing that made me miss work. I picked it because a coworker and his husband had visible success, and it's approved, so my doctor and I could talk straight. I thought about tirzepatide since it's more familiar to people, but this felt simpler.
34-year-old realtor here. I started liraglutide mainly because it was the first GLP-1 my doctor brought up, and I didn't know much about the other options yet. Did 0.6 mg daily for a week, then 1.2, then 1.8 mg over about 3 months. Down 18 lbs, appetite is way quieter, and my afternoon snack cravings mostly vanished. Some nausea and constipation early on, but it faded. The daily injection is kind of a hassle with showings, so I sometimes wish it was weekly. Still, I feel leaner, my A1C dropped a bit, and BP seems a touch lower. I'd stick with it.
I’m 31, a graphic designer, and totally new to peptides. I didn’t want to stack tesamorelin right away, so I ran liraglutide solo. Started at 0.6 mg daily for a week, then 1.2 mg for four weeks, then 1.8 mg for eight weeks. Down 14 lbs, from 198 to 184, and my waist dropped about 2 inches. Visceral fat isn’t something I can measure exactly, but my pants fit way better. Appetite was much quieter, especially late-night snacking. Side effects: mild nausea first 10 days, some constipation. No major issues. It’s daily, which is annoying, but I’d do it again.
34 y/o retired mechanic here. Ran liraglutide about 4 months. Started 0.6 mg daily, bumped to 1.2, then 1.8 mg. Lost 18 lbs, waist down 2 inches. Appetite dropped a lot, especially late-night snacking. A1c went 5.9 to 5.4. Triglycerides dropped 40 points, LDL 15. Nausea first couple weeks, some heartburn, injection site bruises. Resting heart rate up maybe 6 bpm. I wanted the newest option, but insurance pushed me here. Results are solid, not magic. Daily pinning is annoying. If covered, worth it.
Started liraglutide about four months ago. My uncle had good results, so my doctor and I went with it since it’s approved and he knew the dosing. I did 0.6 mg for a week, then 1.2, and now 1.8 mg daily. Down 17 lbs, lost about 2 inches off my waist. Appetite is much quieter, but I get nausea if I eat too fast. First couple weeks had headaches. It’s a daily shot, which is annoying compared to weekly stuff, but it works for me. A1c dropped from 5.8 to 5.4, and BP is down a bit. No crazy side effects after adjusting.
Started liraglutide at 0.6mg for a week, bumped to 1.2, been sitting at 1.8mg for close to three months now. Down 17 lbs and about 2.5 inches off my waist — my work blazers finally button without that pinch. Appetite is honestly the big one, I forget to eat lunch some showing days. Nausea hit me the first two weeks and constipation lingers a bit, nothing that kept me out of the car. My real goal was visceral fat, so I'm letting tesamorelin sit in the drawer until my back heals and I can add lifting back in with my hiking. A1c went 5.6 to 5.2.
I’m 45 and teach middle school, so my days are chaotic. Started liraglutide at 0.6 mg for a week, then 1.2 mg, now 1.8 mg daily for about 7 months. Down 17 lbs, appetite much quieter, A1c from 6.1 to 5.5. Nausea hit mostly after dose jumps, plus some constipation and a little fatigue. I considered newer weekly options; they seem stronger on fat and triglycerides, but higher cost, more side effects, and less long-term data made me nervous. I wanted the shiny new thing, but insurance said no. Sticking with this for now.
45 y/o accountant here. Started liraglutide at 0.6 mg for a week, then 1.2, now on 1.8 mg for about four months. Down from 236 to 209 lbs. Body fat went from 32% to 27%, so around 5 points. A1c dropped 6.2 to 5.6. Appetite is way more manageable, especially late-night snacking. First two weeks I had nausea and some constipation, but it faded. With my starting body fat, I didn't obsess over whether it was visceral or subcutaneous. Clothes fit better and bloodwork improved. Daily injection is a minor hassle.
I'm a 55-year-old software dev. Started liraglutide at 0.6 mg daily, titrated to 1.8 mg over six months. Appetite dropped by week two, so I stopped desk grazing. Nausea and constipation hit the first three weeks, then faded. I went 232 to 210 lbs, waist 42 to 39 inches, A1c 5.9 to 5.5. Belly shrank and liver enzymes improved. Visceral fat likely fell mostly from overall weight loss, no glucagon trick here. I lift and eat protein to protect lean mass. Daily shots are a hassle, but it worked for me.
I’m a 43 y/o PT, started liraglutide at 0.6 mg for a week, then 1.2, settled at 1.8 mg for about 12 weeks. Down 18 lbs, waist 3 inches. Body fat went from 28% to 22.8%, so that 5% drop really shows in my shoulders and midsection. Appetite is way down, and my A1c improved from 5.7 to 5.3. Nausea hit me the first two weeks, plus some constipation, but both eased. If your body fat is higher, don't overthink which fat you're losing—5% off changes your look and labs. Good, not magic.
I’m a 36-year-old graphic designer and started liraglutide 10 weeks ago. I did 0.6 mg for a week, 1.2 mg for two, then settled at 1.8 mg. Down 13 lbs, appetite is much quieter, and I actually stop eating when full. Nausea hit me the first few days after each increase, plus constipation. A friend had great results, and my doctor was comfortable because it’s been approved for years. I considered semaglutide, but this was easier to get covered. Daily injection is a pain, but manageable. Energy and fasting glucose are better too.
31 y/o graphic designer, never used peptides before. Started liraglutide 0.6 mg for a week, then 1.2 mg for 3 weeks, then 1.8 mg for 5 weeks. Didn't stack anything because I was nervous. Waist went from 38.5 to 36.8 in, scale down 9 lbs. Appetite was much quieter, especially late-night snacking. Mild nausea first 10 days and some constipation, but nothing crazy. I still wonder if something like tesamorelin is better for visceral fat, but liraglutide alone gave me modest, real progress. Not a miracle, but worth it if you tolerate it.
Used liraglutide for 8 months. Lost about 10 lbs. It works but weekly options like semaglutide are much more convenient. Good safety profile though - 15 years of data is reassuring.
Lost 14 lbs over 6 months. Works well but having to inject daily is a hassle compared to weekly options. Nausea was manageable. Good option if you want something well-studied with long safety data.